- Title
- How does the GINA definition of control correlate with quality of life and sputum cellularity?
- Creator
- Pizzichini, Marcica Margaret Menezes; Rocha, Cristiane Cinara; de Souza Tavares, Michelle Goncalves; Steidle, Leila John Marques; Maureci da Silva, Rosemeri; dal Pizzol, Felipe; Gibson, Peter G.; Pizzichini, Emilio
- Relation
- ERJ Open Research Vol. 5, Issue 1, p. 1-9
- Publisher Link
- http://dx.doi.org/10.1183/23120541.00146-2018
- Publisher
- European Respiratory Society
- Resource Type
- journal article
- Date
- 2019
- Description
- Since 2014, the Global Initiative for Asthma (GINA) has stated that asthma control should be measured using four questions concerning diurnal and nocturnal symptoms, activity limitation, and rescue medication use. We assessed how asthma control by this definition correlates with airway inflammation and quality of life. 113 asthmatic subjects consecutively recruited from their routine clinical appointment underwent spirometry, sputum induction and answered the Standardised Asthma Quality of Life Questionnaire (AQLQ(S)) during a single visit. 43 (38.1%), 37 (32.7%) and 33 (29.2%) subjects had controlled asthma, partly controlled asthma and uncontrolled asthma, respectively. The majority of subjects with controlled asthma (67.4%) had paucigranulocytic sputum. Eosinophilic sputum was present in all levels of asthma control. Although most subjects with controlled asthma (58.1%) achieved an AQLQ(S) score ⩾6 (minimal or no impairment), the remaining patients (41.9%) had moderate/some impairment (AQLQ(S) score <6 and ⩾3) due to activity impairment and environmental exposure. The present GINA definition of current symptom control reflects control of airway inflammation. However, quality of life impairment can be present even in these patients. Measuring quality of life may provide useful information when evaluating asthma control.
- Subject
- global initiative for Asthma (GINA); asthma; diurnal; airway; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1455518
- Identifier
- uon:45099
- Identifier
- ISSN:2312-0541
- Rights
- ©ERS 2019. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. (https://creativecommons.org/licenses/by-nc/4.0/)
- Language
- eng
- Full Text
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